Scientific research

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Scientific research

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Every year we work on clinical research in order to verify and prove the efficacy and safety of our products.
Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for eve

Research in Low Dose Medicine

Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.

YEAR AUTHORS JOURNAL RESEARCH TYPE TITLE MOLECULES OR COMPOUNDS

2009

Gariboldi S. et al.

Pulmonary Pharmacology & Therapeutics

In vivo basic research

Low Dose oral administration of cytokines for treatment of allergic asthma.

IL-12

IFN-γ

2012

D’amico L. et al.

Journal of Cancer Therapy

Ex vivo basic research

Low Dose of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients.

IL-12

2013 Cardani D. et al. Gastroenterology Research

In vivo basic research

Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation.

IL-10

ANTI IL-1

2014

Roberti M. L. et al.

Journal of Biological Regulatory & Homeostatic Agents Clinial Trial

Immunomodulating treatment with Low Dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris

IL-4

IL-10

2014

Radice E. et al.

International Immunopharmacology

Ex vivo basic research

Low Doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study

IFN-γ

2015

Luchetti P.

Minerva Medica Oftalmologica

Observational retrospective study

Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine.

NT 3

NT4

NGF

2015

Barygina V. et al

Journal of Dermatological Science

In vitro basic research

Treatment with Low Dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin.

IL-4

IL-10

FGF-β

β-endorphin

2015

Lotti T. et al

Journal of Biological Regulatory & Homeostatic Agents

Clinical Trial

Vitiligo: successful combination treatment based on oral Low Dose cytokines and di­fferent topical treatments.

IL-4

IL-10

ANTI IL-1

FGF-β

2015

Radice E. et al

Translational oncology

Ex vivo basic research

Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses of sequential kinetic activated IL-4 and IL-12. A preliminary study.

IL-4

IL-12

2015

Lotti T. et al

Der Hautarzt

Observational retrospective study

Successful combination treatment for Psoriasis with phototherapy and Low Dose Cytokines.

IL-4

IL-10

ANTI IL-1

2015

Tessaro et al.

Journal of Ovarian Research

In vivo basic research

Effect of oral administration of Low Dose follicle stimulating hormone on hyperandrogenized mice as amodel of polycystic ovary syndrome

FSH

2016

Barygina V. et al.

Journal of Dermatological Science

In vivo basic research

Low Dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients.

IL-4

IL-10

FGF-β

β-ENDORPHIN

2016

Fiorito F. et al.

Comparative Immunology, Microbiology and Infectious Diseases

Veterinary study

Clinical improvement in feline herpesvirus 1 infected cats by oral Low Dose of interleukin-12 plus interferon-gamma.

IL-12

IFN-γ

2016

Genazzani A. et al

Frontiers in Gynecological Endocrinology

Observational study

Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea.

β-ESTRADIOL

2016

Uberti F. et al

Cells Tissues Organs

In vitro basic research

Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.

ACH

2017

Tessaro I. et al.

J Reprod Infertil.

In vivo basic research

Ultra Low Dose of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model.

FSH

PROGESTERON

2017

Martin Martin L. S. et al.

Drug Design, Development and Therapy

Clinical Trial

An open randomized active-controlled clinical trial with Low Dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis.

ANTI IL-1

IL-4

IL-10

2017

Carello R. et al.

Italian Journal of Pediatrics

Clinical Trial

Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized control trial.

IL-12

IFN-γ

2017

Castiglioni S. et al.

International Journal of Molecular Sciences

In vitro basic research

Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation.

IFN-γ

2018

Mancini F. et al.

International Immunopharmacology

In vitro basic research

Low Dose SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines.

IL-10

PROGESTERON

2018

Uberti F. et al.

Wound

In vivo basic research

Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo Model

ACH

2018

Tagliacarne S. C. et al.

Immunology Letters

In vivo basic research

Low Dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery.

CITOMIX
2019 Benvenuto M. et al. Experimental and Therapeutic Medicine

In vitro basic research

Effects of a natural multi‐component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts. GALIUM-HEEL

2020

Molinari C. et al.

Brain Sciences

In vitro and in animal model basic research

The Role of BDNF on Aging-Modulation Markers. 

BDNF

2020 Genazzani A. D. et al. Endocrines

Observational study

Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study.

β-ESTRADIOL

2020 Migliore A.
Ravasio R.
AboutOpen Pharmaco-economic study Economic evaluation of low-dose SKA cytokines in patients with rheumatoid arthritis in maintaining low disease activity or remission. IL-4
IL-10
Anti-IL 1
2023 Iuliano M. et al. Current Medicinal Chemistry In vitro study Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model. IL-10
Anti-IL 1
2023 Fioranelli M. et al. Minerva Cardiology and Angiology Clinical study Impact of low-dose Brain-Derived Neurotrophic Factor (BDNF) on atrial fibrillation recurrence BDNF

Medical Devices research

Year Authors Journal Research type Title Medical Device
2016 Martin-Martin L. S. et al. BMC Musculoskeletal Disorders Clinical Trial A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”). MD-KNEE
2018 Randelli F. et al. Cells Ex vivo basic research Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes. MD-TISSUE
2018 Nitecka-Buchta A. et al. Pain Research and Management Clinical Study Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial. MD-MUSCLE
2019 Godek P. Ortopedia Traumatologia Rehabilitacja Clinical Study Collagen Therapy in Lumbar Spondylosis – a Pilot Study. Does the Route of Administration Matter? MD-NEURAL
MD-LUMBAR
2019 Pavelka K. et al. Physiol. Res. Clinical Study
Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients With Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain).
MD-LUMBAR
MD-NEURAL
MD-MUSCLE
2019 Corrado B. et al. Muscles, Ligaments and Tendons Journal

Observational study

Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study. GUNA COLLAGEN MDs
2020 Micarelli A. et al. Eurpean Journal of Physical and Rehabilitation Medicine Clinical Study Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial. GUNA COLLAGEN MDs
2020 Migliore A.
Ravasio R.
AboutOpen Pharmaco-economic study Analisi di minimizzazione dei costi di MD-Knee rispetto all’acido ialuronico nel trattamento di pazienti con osteoartrosi del ginocchio. MD-KNEE
2020 Corrado B. et al. Oxford Medical Case Reports Case report Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report. GUNA COLLAGEN MDs
2020 Corrado B. et al. Journal of Human Sport & Exercise

Observational study

Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: A pilot study and case series. GUNA COLLAGEN MDs
2020 Randelli F. et al. Cells Ex vivo basic research The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured
Human Tenocytes.
MD-TISSUE
2023 Romasco T. et al. Biomedicines In vitro study Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study DENTAL SKIN BIOREGULATION

Food Supplements research

Year Authors Journal Research type Title Food Supplement
2012 Roncuzzi A. et al. Giornale Italiano di Ostetricia e Ginecologia Clinical Trial Efficacia e tollerabilità di Ferroguna versus ferro solfato nel trattamento dell’anemia sideropenica in gravidanza. Studio controllato di non inferiorità FERROGUNA
2014 Cardani D. Minerva Gastroenterol Dietol Ricerca di base in vitro Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull’integrità dei sistemi giunzionali della mucosa intestinale. COLOSTRONONI
2014 Cardani D. Inflammation Cell Signaling Review New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota COLOSTRONONI
2014 Lozzi A. Minerva Cardioangiol Observational retrospective study Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line OMEGA-FORMULA
2016 Chisari G. et al. Minerva Oftalmol Observational study La cosomministrazione dei ceppi batterici Lactobacillus e Bifidobacterium in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell’occhio secco. PROFLORA
2019 Duranti S. et al. Plos One In vitro basic research Exploring the effects of Colostrononi on the mammalian gut microbiota composition. COLOSTRONONI
2021 Berni P. Applied Sciences In vitro basic research In Vitro Evaluation of Cytotoxicity and Proliferative Effects of Lyophilized Porcine Liver Tissue on HepG2 Hepatoma Cells and Adipose-Tissue-Derived Mesenchymal Stromal Cells. EPATOGUNA
2021 Tassinari R. BMC Complementary Medicine and Therapies In vitro basic research Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells. EPATOGUNA