Scientific research
Every year we work on clinical research in order to verify and prove the efficacy and safety of our products.
Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for everyone.
Research in Low Dose Medicine
Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.
YEAR | AUTHORS | JOURNAL | RESEARCH TYPE | TITLE | MOLECULES OR COMPOUNDS |
---|---|---|---|---|---|
2024 | Agosti M. et al . |
European Review for Medical and Pharmacological Sciences |
Delphi Consensus | A low-dose multicomponent medication as a new approach in prevention and early add-on treatment of recurrent respiratory infections in children: a Delphi Consensus. |
Citomix |
2024 |
Cazzaniga A. et al. |
J. Biol. Regul. Homeost. Agents |
Studio pre-clinico | The Different Effects of Pharmacological or Low-Doses of IFN-γ on Endothelial Cells are Mediated by Distinct Intracellular Signalling Pathways. |
IFN-γ |
2023 |
Fioranelli M. et al. |
Minerva Cardiology and Angiology |
Clinical study | Impact of low-dose Brain-Derived Neurotrophic Factor (BDNF) on atrial fibrillation recurrence. |
BDNF |
2023 |
Iuliano M. et al. |
Current Medicinal Chemistry |
In vitro study |
Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model. |
IL-10 |
2020 |
Migliore A. |
AboutOpen |
Pharmaco-economic study |
Economic evaluation of low-dose SKA cytokines in patients with rheumatoid arthritis in maintaining low disease activity or remission. |
IL-4 |
2020 |
Genazzani A. D. et al. |
Endocrines |
Observational study |
Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study. |
β-ESTRADIOL |
2020 |
Molinari C. et al. |
Brain Sciences |
In vitro and in animal model basic research |
The Role of BDNF on Aging-Modulation Markers. |
BDNF |
2019 |
Benvenuto M. et al. |
Experimental and Therapeutic Medicine |
In vitro basic research |
Effects of a natural multi‐component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts. |
GALIUM-HEEL |
2018 |
Tagliacarne S. C. et al. |
Immunology Letters |
In vivo basic research |
Low Dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery. |
CITOMIX |
2018 |
Uberti F. et al. |
Wound |
In vivo basic research |
Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo Model |
ACH |
2018 |
Mancini F. et al. |
International Immunopharmacology |
In vitro basic research |
Low Dose SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines. |
IL-10 PROGESTERON |
2017 |
Castiglioni S. et al. |
International Journal of Molecular Sciences |
In vitro basic research |
Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation. |
IFN-γ |
2017 |
Carello R. et al. |
Italian Journal of Pediatrics |
Clinical Trial |
Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized control trial. |
IL-12 IFN-γ |
2017 |
Martin Martin L. S. et al. |
Drug Design, Development and Therapy |
Clinical Trial |
An open randomized active-controlled clinical trial with Low Dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis. |
ANTI IL-1 IL-4 IL-10 |
2017 |
Tessaro I. et al. |
J Reprod Infertil. |
In vivo basic research |
Ultra Low Dose of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model. |
FSH PROGESTERON |
2016 |
Uberti F. et al |
Cells Tissues Organs |
In vitro basic research |
Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes. |
ACH |
2016 |
Genazzani A. et al |
Frontiers in Gynecological Endocrinology |
Observational study |
Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea. |
β-ESTRADIOL |
2016 |
Fiorito F. et al. |
Comparative Immunology, Microbiology and Infectious Diseases |
Veterinary study |
Clinical improvement of cows with puerperal metritis treated with the homeopathic product 0.01% abies alba and the low dose of neostigmine. |
NEOSTIGMIN |
2016 |
Barygina V. et al. |
Journal of Dermatological Science |
In vivo basic research |
Low Dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients. |
IL-4 IL-10 FGF-β β-ENDORPHIN |
2015 |
Tessaro et al. |
Journal of Ovarian Research |
In vivo basic research |
Effect of oral administration of Low Dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome |
FSH |
2015 |
Lotti T. et al |
Der Hautarzt |
Observational retrospective study |
Successful combination treatment for Psoriasis with phototherapy and Low Dose Cytokines. |
IL-4 IL-10 ANTI IL-1 |
2015 |
Radice E. et al |
Translational oncology |
Ex vivo basic research |
Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses of sequential kinetic activated IL-4 and IL-12. A preliminary study. |
IL-4 IL-12 |
2015 |
Lotti T. et al |
Journal of Biological Regulatory & Homeostatic Agents |
Clinical Trial |
Vitiligo: successful combination treatment based on oral Low Dose cytokines and different topical treatments. |
IL-4 IL-10 ANTI IL-1 FGF-β |
2015 |
Barygina V. et al |
Journal of Dermatological Science |
In vitro basic research |
Treatment with Low Dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin. |
IL-4 IL-10 FGF-β β-endorphin |
2015 |
Luchetti P. |
Minerva Medica Oftalmologica |
Observational retrospective study |
Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine. |
NT 3 NT4 NGF |
2014 |
Radice E. et al. |
International Immunopharmacology |
Ex vivo basic research |
Low Doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study |
IFN-γ |
2014 |
Roberti M. L. et al. |
Journal of Biological Regulatory & Homeostatic Agents |
Clinical Trial |
Immunomodulating treatment with Low Dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris |
IL-4 IL-10 |
2013 |
Cardani D. et al. |
Gastroenterology Research |
In vivo basic research |
Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation. |
IL-10 ANTI IL-1 |
2012 |
D’amico L. et al. |
Journal of Cancer Therapy |
Ex vivo basic research |
Low Dose of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients. |
IL-12 |
2009 |
Gariboldi S. et al. |
Pulmonary Pharmacology & Therapeutics |
In vivo basic research |
Low Dose oral administration of cytokines for treatment of allergic asthma. |
IL-12 IFN-γ |
Medical Devices research
Year | Authors | Journal | Research type | Title | Medical Device |
---|---|---|---|---|---|
2023 | Romasco T. et al. | Biomedicines | In vitro study | Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study | DENTAL SKIN BIOREGULATION |
2020 | Randelli F. et al. | Cells | Ex vivo basic research | The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes. | MD-TISSUE |
2020 | Corrado B. et al. | Journal of Human Sport & Exercise | Observational study | Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: A pilot study and case series. | GUNA COLLAGEN MDs |
2020 | Corrado B. et al. | Oxford Medical Case Reports | Case report | Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report. | GUNA COLLAGEN MDs |
2020 | Migliore A. | AboutOpen | Pharmaco-economic study | Analisi di minimizzazione dei costi di MD-Knee rispetto all’acido ialuronico nel trattamento di pazienti con osteoartrosi del ginocchio. | MD-KNEE |
2020 | Micarelli A. et al. | Eurpean Journal of Physical and Rehabilitation Medicine | Clinical Study | Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial. | GUNA COLLAGEN MDs |
2019 | Corrado B. et al. | Muscles, Ligaments and Tendons Journal | Observational study | Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study. | GUNA COLLAGEN MDs |
2019 | Pavelka K. et al. | Physiol. Res. | Clinical Study | Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients With Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain). | MD-LUMBAR |
2019 | Godek P. | Ortopedia Traumatologia Rehabilitacja | Clinical Study | Collagen Therapy in Lumbar Spondylosis – a Pilot Study. Does the Route of Administration Matter? | MD-NEURAL |
2018 | Nitecka-Buchta A. et al. | Pain Research and Management | Clinical Study | Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial. | MD-MUSCLE |
2018 | Randelli F. et al. | Cells | Ex vivo basic research | Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes. | MD-TISSUE |
2016 | Martin-Martin L. S. et al. | BMC Musculoskeletal Disorders | Clinical Trial | A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”). | MD-KNEE |
Food Supplements research
Year | Authors | Journal | Research type | Title | Food Supplement |
---|---|---|---|---|---|
2021 | Tassinari R. | BMC Complementary Medicine and Therapies | In vitro basic research | Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells. | EPATOGUNA |
2021 | Berni P. | Applied Sciences | In vitro basic research | In Vitro Evaluation of Cytotoxicity and Proliferative Effects of Lyophilized Porcine Liver Tissue on HepG2 Hepatoma Cells and Adipose-Tissue-Derived Mesenchymal Stromal Cells. | EPATOGUNA |
2019 | Duranti S. et al. | Plos One | In vitro basic research | Exploring the effects of Colostrononi on the mammalian gut microbiota composition. | COLOSTRONONI |
2016 | Chisari G. et al. | Minerva Oftalmol | Observational study | La cosomministrazione dei ceppi batterici Lactobacillus e Bifidobacterium in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell’occhio secco. | PROFLORA |
2014 | Lozzi A. | Minerva Cardioangiol | Observational retrospective study | Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line | OMEGA-FORMULA |
2014 | Cardani D. | Inflammation Cell Signaling | Review | New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota | COLOSTRONONI |
2014 | Cardani D. | Minerva Gastroenterol Dietol | Ricerca di base in vitro | Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull’integrità dei sistemi giunzionali della mucosa intestinale. | COLOSTRONONI |
2012 | Roncuzzi A. et al. | Giornale Italiano di Ostetricia e Ginecologia | Clinical Trial | Efficacia e tollerabilità di Ferroguna versus ferro solfato nel trattamento dell’anemia sideropenica in gravidanza. Studio controllato di non inferiorità | FERROGUNA |