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Scientific research

Every year we work on clinical research in order to verify and prove the efficacy and safety of our products.

Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for everyone.

Research in Low Dose Medicine

Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.
 

Year

Authors

Journal

Research type

Title

Molecules or compounds

2009

Gariboldi S. et al.

Pulmonary Pharmacology & Therapeutics

In vivo basic research

Low Dose oral administration of cytokines for treatment of allergic asthma.

IL-12

IFN-γ

2012

D’amico L. et al.

Journal of Cancer Therapy

Ex vivo basic research

Low Dose of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients.

IL-12

2013

Cardani D. et al.

Gastroenterology Research

In vivo basic research

Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation.

IL-10

ANTI IL-1

2014

Roberti M. L. et al.

Journal of Biological Regulatory & Homeostatic Agents

Clinial Trial

Immunomodulating treatment with Low Dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris

IL-4

IL-10

2014

Radice E. et al.

International Immunopharmacology

Ex vivo basic research

Low Doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study.

IFN-γ

2015

Luchetti P.

Minerva Medica Oftalmologica

Observational retrospective study

Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine.

NT3

NT4

NGF

2015

Barygina V. et al

Journal of Dermatological Science

In vitro basic research

Treatment with Low Dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin.

IL-4

IL-10

FGF-β

β-endorphin

2015

Lotti T. et al

Journal of Biological Regulatory & Homeostatic Agents

Clinical Trial

Vitiligo: successful combination treatment based on oral Low Dose cytokines and di­fferent topical treatments.

IL-4

IL-10

ANTI IL-1

FGF-β

2015

Radice E. et al

Translational oncology

Ex vivo basic research

Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses of sequential kinetic activated IL-4 and IL-12. A preliminary study.

IL-4

IL-12

2015

Lotti T. et al

Der Hautarzt

Observational retrospective study

Successful combination treatment for Psoriasis with phototherapy and Low Dose Cytokines.

IL-4

IL-10

ANTI IL-1

2015

Tessaro et al.

Journal of Ovarian Research

In vivo basic research

Effect of oral administration of Low Dose follicle stimulating hormone on hyperandrogenized mice as amodel of polycystic ovary syndrome

FSH

2016

Barygina V. et al.

Journal of Dermatological Science

In vivo basic research

Low Dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients.

IL-4

IL-10

FGF-β

β-ENDORPHIN

2016

Fiorito F. et al.

Comparative Immunology, Microbiology and Infectious Diseases

Veterinary study

Clinical improvement in feline herpesvirus 1 infected cats by oral Low Dose of interleukin-12 plus interferon-gamma.

IL-12

IFN-γ

2016

Genazzani A. et al Frontiers in Gynecological Endocrinology Observational study Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea.

β-ESTRADIOL

 

2016

Uberti F. et al

Cells Tissues Organs

In vitro basic research

Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.

 
ACH

2017

Tessaro I. et al.

J Reprod Infertil.

In vivo basic research

Ultra Low Dose of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model.

FSH

PROGESTERON

2017

Martin Martin L. S. et al. Drud Design, Development and Therapy Clinical Trial An open randomized active-controlled clinical trial with Low Dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis.

ANTI IL-1

IL-4

IL-10

2017

Carello R. et al.

Italian Journal of Pediatrics

Clinical Trial

Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized control trial.

IL-12

IFN-γ

2017

Castiglioni S. et al.

International Journal of Molecular Sciences

In vitro basic research

Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation.

IFN-γ
2018

Mancini F. et al.

International Immunopharmacology

In vitro basic research

Low Dose SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines.

IL-10

PROGESTERON

2018

Uberti F. et al.

Wound

In vivo basic research

Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo Model

ACH

2018

Tagliacarne S. C. et al.

Immunology Letters

Ex vivo basic research

Low Dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery.

CITOMIX

2020

Molinari C. et al.

Brain Sciences

In vitro and in animal model basic research

The Role of BDNF on Aging-Modulation Markers. 

BDNF

Medical Devices research

Year

Authors

Journal

Research type

Title

Medical Device

2016

Martin-Martin L. S. et al.

BMC Musculoskeletal Disorders

Clinical Trial

A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”).

MD-KNEE

2018

Randelli F. et al.

Cells

Ex vivo basic research

Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes.

MD-TISSUE

2018

Nitecka-Buchta A. et al.

Pain Research and Management

Clinical Study

Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial.

MD-MUSCLE

Food Supplements research

Year

Authors

Journal

Research type

Title

Food Supplement

2012

Roncuzzi A. et al.

Giornale Italiano di Ostetricia e Ginecologia

Clinical Trial

Efficacia e tollerabilità di Ferroguna versus ferro solfato nel trattamento dell’anemia sideropenica in gravidanza. Studio controllato di non inferiorità.

FERROGUNA

2014

Cardani D.

Minerva Gastroenterol Dietol

In vitro basic research

Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull’integrità dei sistemi giunzionali della mucosa intestinale.

COLOSTRONONI

2014

Cardani D.

Inflammation & Cell Signaling 

Review

New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota

COLOSTRONONI

2014

Lozzi A.

Minerva Cardioangiol

Observational retrospective study

Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line

OMEGA-FORMULA

2016

Chisari G. et al.

Minerva Oftalmol

Observational study

La cosomministrazione dei ceppi batterici Lactobacillus e Bifidobacterium in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell’occhio secco.

PROFLORA

2019

Duranti S. et al.

Plos One

In vitro basic research

Exploring the effects of Colostrononi on the mammalian gut microbiota composition.

COLOSTRONONI