Scientific research
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Every year we work on clinical research in order to verify and prove the efficacy and safety of our products.
Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for eve
Research in Low Dose Medicine
Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.
YEAR | AUTHORS | JOURNAL | RESEARCH TYPE | TITLE | MOLECULES OR COMPOUNDS |
---|---|---|---|---|---|
2009 |
Gariboldi S. et al. |
Pulmonary Pharmacology & Therapeutics |
In vivo basic research |
Low Dose oral administration of cytokines for treatment of allergic asthma. |
IL-12 IFN-γ |
2012 | D’amico L. et al. |
Journal of Cancer Therapy |
Ex vivo basic research |
Low Dose of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients. |
IL-12 |
2013 | Cardani D. et al. | Gastroenterology Research | In vivo basic research |
Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation. |
IL-10 ANTI IL-1 |
2014 |
Roberti M. L. et al. |
Journal of Biological Regulatory & Homeostatic Agents | Clinial Trial | Immunomodulating treatment with Low Dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris |
IL-4 IL-10 |
2014 |
Radice E. et al. | International Immunopharmacology |
Ex vivo basic research |
Low Doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study |
IFN-γ |
2015 |
Luchetti P. |
Minerva Medica Oftalmologica |
Observational retrospective study |
Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine. |
NT 3 NT4 NGF |
2015 |
Barygina V. et al |
Journal of Dermatological Science |
In vitro basic research |
Treatment with Low Dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin. |
IL-4 IL-10 FGF-β β-endorphin |
2015 |
Lotti T. et al |
Journal of Biological Regulatory & Homeostatic Agents |
Clinical Trial |
Vitiligo: successful combination treatment based on oral Low Dose cytokines and different topical treatments. |
IL-4 IL-10 ANTI IL-1 FGF-β |
2015 | Radice E. et al |
Translational oncology |
Ex vivo basic research |
Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses of sequential kinetic activated IL-4 and IL-12. A preliminary study. |
IL-4 IL-12 |
2015 |
Lotti T. et al |
Der Hautarzt |
Observational retrospective study |
Successful combination treatment for Psoriasis with phototherapy and Low Dose Cytokines. |
IL-4 IL-10 ANTI IL-1 |
2015 |
Tessaro et al. |
Journal of Ovarian Research |
In vivo basic research |
Effect of oral administration of Low Dose follicle stimulating hormone on hyperandrogenized mice as amodel of polycystic ovary syndrome |
FSH |
2016 |
Barygina V. et al. |
Journal of Dermatological Science |
In vivo basic research |
Low Dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients. | IL-4 IL-10 FGF-β β-ENDORPHIN |
2016 |
Fiorito F. et al. |
Comparative Immunology, Microbiology and Infectious Diseases |
Veterinary study |
Clinical improvement in feline herpesvirus 1 infected cats by oral Low Dose of interleukin-12 plus interferon-gamma. |
IL-12 IFN-γ |
2016 |
Genazzani A. et al |
Frontiers in Gynecological Endocrinology |
Observational study |
Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea. |
β-ESTRADIOL |
2016 |
Uberti F. et al |
Cells Tissues Organs | In vitro basic research |
Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes. |
ACH |
2017 |
Tessaro I. et al. |
J Reprod Infertil. | In vivo basic research |
Ultra Low Dose of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model. |
FSH PROGESTERON |
2017 |
Martin Martin L. S. et al. |
Drug Design, Development and Therapy |
Clinical Trial | An open randomized active-controlled clinical trial with Low Dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis. |
ANTI IL-1 IL-4 IL-10 |
2017 |
Carello R. et al. |
Italian Journal of Pediatrics |
Clinical Trial |
Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized control trial. |
IL-12 IFN-γ |
2017 |
Castiglioni S. et al. |
International Journal of Molecular Sciences |
In vitro basic research |
Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation. |
IFN-γ |
2018 |
Mancini F. et al. |
International Immunopharmacology |
In vitro basic research |
Low Dose SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines. |
IL-10 PROGESTERON |
2018 |
Uberti F. et al. |
Wound | In vivo basic research |
Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo Model |
ACH |
2018 |
Tagliacarne S. C. et al. |
Immunology Letters | In vivo basic research |
Low Dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery. |
CITOMIX |
2019 | Benvenuto M. et al. | Experimental and Therapeutic Medicine | In vitro basic research |
Effects of a natural multi‐component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts. | GALIUM-HEEL |
2020 |
Molinari C. et al. |
Brain Sciences | In vitro and in animal model basic research |
The Role of BDNF on Aging-Modulation Markers. |
BDNF |
2020 | Genazzani A. D. et al. | Endocrines | Observational study |
Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study. | β-ESTRADIOL |
2020 | Migliore A. Ravasio R. |
AboutOpen | Pharmaco-economic study | Economic evaluation of low-dose SKA cytokines in patients with rheumatoid arthritis in maintaining low disease activity or remission. | IL-4 IL-10 Anti-IL 1 |
2023 | Iuliano M. et al. | Current Medicinal Chemistry | In vitro study | Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model. | IL-10 Anti-IL 1 |
2023 | Fioranelli M. et al. | Minerva Cardiology and Angiology | Clinical study | Impact of low-dose Brain-Derived Neurotrophic Factor (BDNF) on atrial fibrillation recurrence | BDNF |
Medical Devices research
Year | Authors | Journal | Research type | Title | Medical Device |
---|---|---|---|---|---|
2016 | Martin-Martin L. S. et al. | BMC Musculoskeletal Disorders | Clinical Trial | A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”). | MD-KNEE |
2018 | Randelli F. et al. | Cells | Ex vivo basic research | Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes. | MD-TISSUE |
2018 | Nitecka-Buchta A. et al. | Pain Research and Management | Clinical Study | Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial. | MD-MUSCLE |
2019 | Godek P. | Ortopedia Traumatologia Rehabilitacja | Clinical Study | Collagen Therapy in Lumbar Spondylosis – a Pilot Study. Does the Route of Administration Matter? | MD-NEURAL MD-LUMBAR |
2019 | Pavelka K. et al. | Physiol. Res. | Clinical Study |
Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients With Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain). |
MD-LUMBAR MD-NEURAL MD-MUSCLE |
2019 | Corrado B. et al. | Muscles, Ligaments and Tendons Journal | Observational study |
Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study. | GUNA COLLAGEN MDs |
2020 | Micarelli A. et al. | Eurpean Journal of Physical and Rehabilitation Medicine | Clinical Study | Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial. | GUNA COLLAGEN MDs |
2020 | Migliore A. Ravasio R. |
AboutOpen | Pharmaco-economic study | Analisi di minimizzazione dei costi di MD-Knee rispetto all’acido ialuronico nel trattamento di pazienti con osteoartrosi del ginocchio. | MD-KNEE |
2020 | Corrado B. et al. | Oxford Medical Case Reports | Case report | Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report. | GUNA COLLAGEN MDs |
2020 | Corrado B. et al. | Journal of Human Sport & Exercise | Observational study |
Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: A pilot study and case series. | GUNA COLLAGEN MDs |
2020 | Randelli F. et al. | Cells | Ex vivo basic research | The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes. |
MD-TISSUE |
2023 | Romasco T. et al. | Biomedicines | In vitro study | Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study | DENTAL SKIN BIOREGULATION |
Food Supplements research
Year | Authors | Journal | Research type | Title | Food Supplement |
---|---|---|---|---|---|
2012 | Roncuzzi A. et al. | Giornale Italiano di Ostetricia e Ginecologia | Clinical Trial | Efficacia e tollerabilità di Ferroguna versus ferro solfato nel trattamento dell’anemia sideropenica in gravidanza. Studio controllato di non inferiorità | FERROGUNA |
2014 | Cardani D. | Minerva Gastroenterol Dietol | Ricerca di base in vitro | Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull’integrità dei sistemi giunzionali della mucosa intestinale. | COLOSTRONONI |
2014 | Cardani D. | Inflammation Cell Signaling | Review | New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota | COLOSTRONONI |
2014 | Lozzi A. | Minerva Cardioangiol | Observational retrospective study | Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line | OMEGA-FORMULA |
2016 | Chisari G. et al. | Minerva Oftalmol | Observational study | La cosomministrazione dei ceppi batterici Lactobacillus e Bifidobacterium in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell’occhio secco. | PROFLORA |
2019 | Duranti S. et al. | Plos One | In vitro basic research | Exploring the effects of Colostrononi on the mammalian gut microbiota composition. | COLOSTRONONI |
2021 | Berni P. | Applied Sciences | In vitro basic research | In Vitro Evaluation of Cytotoxicity and Proliferative Effects of Lyophilized Porcine Liver Tissue on HepG2 Hepatoma Cells and Adipose-Tissue-Derived Mesenchymal Stromal Cells. | EPATOGUNA |
2021 | Tassinari R. | BMC Complementary Medicine and Therapies | In vitro basic research | Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells. | EPATOGUNA |