Scientific research

Every year we work on clinical research in order to verify and prove the efficacy and safety of our products.
Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for everyone.

Research in Low Dose Medicine
Medical Devices research
Food Supplements research

Research in Low Dose Medicine

Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.

YEAR	AUTHORS	JOURNAL	RESEARCH TYPE	TITLE	MOLECULES OR COMPOUNDS
2024	Agosti M. et al .	European Review for Medical and Pharmacological Sciences	Delphi Consensus	A low-dose multicomponent medication as a new approach in prevention and early add-on treatment of recurrent respiratory infections in children: a Delphi Consensus.	Citomix
2024	Cazzaniga A. et al.	J. Biol. Regul. Homeost. Agents	Studio pre-clinico	The Different Effects of Pharmacological or Low-Doses of IFN-γ on Endothelial Cells are Mediated by Distinct Intracellular Signalling Pathways.	IFN-γ
2023	Fioranelli M. et al.	Minerva Cardiology and Angiology	Clinical study	Impact of low-dose Brain-Derived Neurotrophic Factor (BDNF) on atrial fibrillation recurrence.	BDNF
2023	Iuliano M. et al.	Current Medicinal Chemistry	In vitro study	Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model.	IL-10 Anti-IL 1
2020	Migliore A. Ravasio R.	AboutOpen	Pharmaco-economic study	Economic evaluation of low-dose SKA cytokines in patients with rheumatoid arthritis in maintaining low disease activity or remission.	IL-4 IL-10 Anti-IL 1
2020	Genazzani A. D. et al.	Endocrines	Observational study	Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study.	β-ESTRADIOL
2020	Molinari C. et al.	Brain Sciences	In vitro and in animal model basic research	The Role of BDNF on Aging-Modulation Markers.	BDNF
2019	Benvenuto M. et al.	Experimental and Therapeutic Medicine	In vitro basic research	Effects of a natural multi‐component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts.	GALIUM-HEEL
2018	Tagliacarne S. C. et al.	Immunology Letters	In vivo basic research	Low Dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery.	CITOMIX
2018	Uberti F. et al.	Wound	In vivo basic research	Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo Model	ACH
2018	Mancini F. et al.	International Immunopharmacology	In vitro basic research	Low Dose SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines.	IL-10 PROGESTERON
2017	Castiglioni S. et al.	International Journal of Molecular Sciences	In vitro basic research	Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation.	IFN-γ
2017	Carello R. et al.	Italian Journal of Pediatrics	Clinical Trial	Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized control trial.	IL-12 IFN-γ
2017	Martin Martin L. S. et al.	Drug Design, Development and Therapy	Clinical Trial	An open randomized active-controlled clinical trial with Low Dose SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis.	ANTI IL-1 IL-4 IL-10
2017	Tessaro I. et al.	J Reprod Infertil.	In vivo basic research	Ultra Low Dose of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model.	FSH PROGESTERON
2016	Uberti F. et al	Cells Tissues Organs	In vitro basic research	Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.	ACH
2016	Genazzani A. et al	Frontiers in Gynecological Endocrinology	Observational study	Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea.	β-ESTRADIOL
2016	Fiorito F. et al.	Comparative Immunology, Microbiology and Infectious Diseases	Veterinary study	Clinical improvement of cows with puerperal metritis treated with the homeopathic product 0.01% abies alba and the low dose of neostigmine.	NEOSTIGMIN
2016	Barygina V. et al.	Journal of Dermatological Science	In vivo basic research	Low Dose cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients.	IL-4 IL-10 FGF-β β-ENDORPHIN
2015	Tessaro et al.	Journal of Ovarian Research	In vivo basic research	Effect of oral administration of Low Dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome	FSH
2015	Lotti T. et al	Der Hautarzt	Observational retrospective study	Successful combination treatment for Psoriasis with phototherapy and Low Dose Cytokines.	IL-4 IL-10 ANTI IL-1
2015	Radice E. et al	Translational oncology	Ex vivo basic research	Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses of sequential kinetic activated IL-4 and IL-12. A preliminary study.	IL-4 IL-12
2015	Lotti T. et al	Journal of Biological Regulatory & Homeostatic Agents	Clinical Trial	Vitiligo: successful combination treatment based on oral Low Dose cytokines and different topical treatments.	IL-4 IL-10 ANTI IL-1 FGF-β
2015	Barygina V. et al	Journal of Dermatological Science	In vitro basic research	Treatment with Low Dose cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin.	IL-4 IL-10 FGF-β β-endorphin
2015	Luchetti P.	Minerva Medica Oftalmologica	Observational retrospective study	Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose Medicine.	NT 3 NT4 NGF
2014	Radice E. et al.	International Immunopharmacology	Ex vivo basic research	Low Doses of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study	IFN-γ
2014	Roberti M. L. et al.	Journal of Biological Regulatory & Homeostatic Agents	Clinical Trial	Immunomodulating treatment with Low Dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris	IL-4 IL-10
2013	Cardani D. et al.	Gastroenterology Research	In vivo basic research	Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation.	IL-10 ANTI IL-1
2012	D’amico L. et al.	Journal of Cancer Therapy	Ex vivo basic research	Low Dose of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients.	IL-12
2009	Gariboldi S. et al.	Pulmonary Pharmacology & Therapeutics	In vivo basic research	Low Dose oral administration of cytokines for treatment of allergic asthma.	IL-12 IFN-γ

Medical Devices research

Year	Authors	Journal	Research type	Title	Medical Device
2023	Romasco T. et al.	Biomedicines	In vitro study	Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study	DENTAL SKIN BIOREGULATION
2020	Randelli F. et al.	Cells	Ex vivo basic research	The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes.	MD-TISSUE
2020	Corrado B. et al.	Journal of Human Sport & Exercise	Observational study	Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: A pilot study and case series.	GUNA COLLAGEN MDs
2020	Corrado B. et al.	Oxford Medical Case Reports	Case report	Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report.	GUNA COLLAGEN MDs
2020	Migliore A. Ravasio R.	AboutOpen	Pharmaco-economic study	Analisi di minimizzazione dei costi di MD-Knee rispetto all’acido ialuronico nel trattamento di pazienti con osteoartrosi del ginocchio.	MD-KNEE
2020	Micarelli A. et al.	Eurpean Journal of Physical and Rehabilitation Medicine	Clinical Study	Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial.	GUNA COLLAGEN MDs
2019	Corrado B. et al.	Muscles, Ligaments and Tendons Journal	Observational study	Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study.	GUNA COLLAGEN MDs
2019	Pavelka K. et al.	Physiol. Res.	Clinical Study	Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients With Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain).	MD-LUMBAR MD-NEURAL MD-MUSCLE
2019	Godek P.	Ortopedia Traumatologia Rehabilitacja	Clinical Study	Collagen Therapy in Lumbar Spondylosis – a Pilot Study. Does the Route of Administration Matter?	MD-NEURAL MD-LUMBAR
2018	Nitecka-Buchta A. et al.	Pain Research and Management	Clinical Study	Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial.	MD-MUSCLE
2018	Randelli F. et al.	Cells	Ex vivo basic research	Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes.	MD-TISSUE
2016	Martin-Martin L. S. et al.	BMC Musculoskeletal Disorders	Clinical Trial	A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”).	MD-KNEE

Food Supplements research

Year	Authors	Journal	Research type	Title	Food Supplement
2021	Tassinari R.	BMC Complementary Medicine and Therapies	In vitro basic research	Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells.	EPATOGUNA
2021	Berni P.	Applied Sciences	In vitro basic research	In Vitro Evaluation of Cytotoxicity and Proliferative Effects of Lyophilized Porcine Liver Tissue on HepG2 Hepatoma Cells and Adipose-Tissue-Derived Mesenchymal Stromal Cells.	EPATOGUNA
2019	Duranti S. et al.	Plos One	In vitro basic research	Exploring the effects of Colostrononi on the mammalian gut microbiota composition.	COLOSTRONONI
2016	Chisari G. et al.	Minerva Oftalmol	Observational study	La cosomministrazione dei ceppi batterici Lactobacillus e Bifidobacterium in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell’occhio secco.	PROFLORA
2014	Lozzi A.	Minerva Cardioangiol	Observational retrospective study	Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line	OMEGA-FORMULA
2014	Cardani D.	Inflammation Cell Signaling	Review	New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota	COLOSTRONONI
2014	Cardani D.	Minerva Gastroenterol Dietol	Ricerca di base in vitro	Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull’integrità dei sistemi giunzionali della mucosa intestinale.	COLOSTRONONI
2012	Roncuzzi A. et al.	Giornale Italiano di Ostetricia e Ginecologia	Clinical Trial	Efficacia e tollerabilità di Ferroguna versus ferro solfato nel trattamento dell’anemia sideropenica in gravidanza. Studio controllato di non inferiorità	FERROGUNA