{"id":2335,"date":"2022-01-27T16:23:36","date_gmt":"2022-01-27T15:23:36","guid":{"rendered":"https:\/\/guna.com\/blog\/products\/gunavit-b5-plus\/"},"modified":"2022-08-01T16:40:30","modified_gmt":"2022-08-01T14:40:30","slug":"gunavit-b5-plus","status":"publish","type":"products","link":"https:\/\/guna.com\/products\/food-supplements\/gunavit-b5-plus\/","title":{"rendered":"GunaVit B5 PLUS<\/i><\/b>"},"content":{"rendered":"
Food supplement with Sunflower derived Phosphatidylserine, Vitamin D3, Vitamin B5 and Selenium<\/h5>\n
    \n
  • Gluten and fructose free<\/li>\n
  • Veg-friendly<\/li>\n
  • Naturally lactose free<\/li>\n
  • No added sugar<\/li>\n<\/ul>\n

    Description<\/h4>\n

    In addition to their energetic action, the nutrients obtained through food play an essential role in the PNEI (Psycho-Neuro-Endocrine-Immunology) regulation process.\u00a0<\/span><\/p>\n

    In fact, when affected by certain conditions, the body needs a bigger amount of nutrients to support its homeostatic processes. In other cases, conditions can be the reflection of a decreased dietary intake, such as for example:\u00a0<\/span><\/p>\n

      \n
    • more or less prolonged states of fatigue and tiredness<\/b><\/li>\n
    • excessive oxidative stress1<\/sup><\/b><\/li>\n
    • intense mental activity<\/b><\/li>\n<\/ul>\n

      \"GunaVit-B5-PLUS---intense-mental-activity\"<\/p>\n

      Active Ingredients<\/h4>\n

      GunaVit B5 PLUS <\/i><\/b>provides a balanced and synergistic supply of nutritional elements: Vitamin B5 (Pantothenic acid) contributes to reducing fatigue <\/b>and to normal brain performance<\/b>; Vitamin D <\/b>contributes to maintaining muscle health <\/b>and, along with Selenium<\/b>, supports the normal functioning of the immune system<\/b>. Moreover, Selenium <\/b>also assists in the processes that protect cells from oxidative stress<\/b>.<\/p>\n

      PHOSPHATIDYLSERINE (PS)<\/b>2-7<\/b><\/sup>: <\/b>GunaVit B5 PLUS <\/i><\/b>contains PS standardized to 60% <\/b>from Sunflower Phospholipids<\/b>.
      \nPS is a lipid concentrated especially in the brain (15% of phospholipids) and localized in the cell membrane (towards the cytoplasmic layer). It participates in the mechanisms of depolarization of neuronal membranes<\/b>, in the release of neurotransmitters<\/b>, in post-synaptic receptor activities<\/b>, in the activation of Protein Kinase C<\/b>, which is crucial in cognitive and memory processes<\/b>. PS also contributes to supporting the physiological integrity of the mitochondrial membrane responsible for producing energy<\/b>. Several studies indicate that PS is involved in the physiological regulation of cortisol <\/b>and in the physiological regulation of glutathione peroxidase levels<\/b>.\u00a0<\/span><\/p>\n

      SELENIUM (L-Selenomethionine)<\/b>8-11<\/b><\/sup>: <\/b>it is an essential oligo-element that, through selenomethionine, constitutes the glutathione peroxidase. Each capsule of GunaVit B5 PLUS <\/i><\/b>contains about 90% of the daily Nutrient Reference Value (NRV) of Selenium. Selenium <\/b>supports the normal functioning of the immune system <\/b>and the protection of cells from oxidative stress<\/b>.\u00a0<\/span><\/p>\n

      VITAMIN B5 (Calcium pantothenate)<\/b>12-13<\/b><\/sup>: <\/b>it is an essential vitamin that, being water-soluble, cannot be accumulated in the body. Vitamin B5 is a constituent of the Coenzyme A (CoA). Each capsule of GunaVit B5 PLUS <\/i><\/b>contains more than 100% of the daily Nutrient Reference Value (NRV) of Vitamin B5, recommended in a balanced nutritional intake.\u00a0<\/span><\/p>\n

      Vitamin B5 contributes to normal energy metabolism<\/b>, normal synthesis<\/b>, and normal metabolism of steroid hormones<\/b>, to the metabolism of Vitamin D and some neurotransmitters<\/b>. It also contributes to reduce fatigue <\/b>and to normal brain performance<\/b>.\u00a0<\/span><\/p>\n

      VITAMIN D3 (Cladonia rangiferina <\/i>(L.) Weber ex F.H. Wigg., thallus) d. e. standardized to 0.25% in vitamin D3 (Cholecalciferol)<\/b>14-15<\/b><\/sup>: <\/b>the standardized Vitamin D3 of GunaVit B5 PLUS <\/i><\/b>is obtained from plant sources, a lichen<\/b>, for a balanced nutritional intake. In the body, Vitamin D3 participates in the\u00a0regulation of various physiological functions, such as the regulation of Ca-P balance and bones mineralization. Deficiency of this vitamin may be due to aging, unbalanced diet, poor exposure to sunlight, intestinal malabsorption.\u00a0<\/span><\/p>\n

      Vitamin D contributes to maintaining the normal function of muscles and the immune system<\/b>.<\/p>\n

      GunaVit B5 PLUS <\/i><\/b>with Phosphatidylserine <\/b>provides a supply of specific nutritional elements, in vegan capsules<\/b>:<\/p>\n

      \"GunaVit-B5-PLUS---Active-ingredients\"<\/p>\n

      Warnings<\/h4>\n

      Do not exceed the recommended daily dose. Keep out of the reach of children under 3 years of age. Food supplements should not be used as a substitute for a varied diet and a healthy lifestyle<\/b>. Store the product in a cool and dry place and protect from light. The expiry date refers to a product correctly stored in its original and undamaged packaging.\u00a0<\/span><\/p>\n

      Nutrition facts<\/h4>\n

      \"\"<\/p>\n

      Ingredients<\/h4>\n

      Bulking agent: microcrystalline cellulose (cellulose gel); hydroxypropyl methylcellulose (capsule ingredient), phospholipids derived from powdered sunflower enriched with phosphatidylserine standardized to 60%, anti-caking agents: silicon dioxide, magnesium salts of fatty acids; Cladonia rangiferina (Cladonia rangiferina<\/em> (L.) Weber ex F.H. Wigg., thallus) d.e. standardized\u00a0to 0.25% in Vitamin D3 (Cholecalciferol), Vitamin B5 (calcium pantothenate), L-Selenomethionine.<\/p>\n

      Instructions for use<\/h4>\n

      We recommend taking 2 capsules per day, to be swallowed with a glass of water, for ten days, and continue with 1 capsule per day for the following 10 days.<\/p>\n

      Packaging<\/h4>\n

      Package of 30 swallowable capsules. Net weight 12.8 g \u212e.<\/p>\n

      \n

      References<\/h4>\n

      1. Yahaya Muhammad, Yamuna Aminu Kani, Sani Iliya, Jafaru Bunza Muhammad, Abubakar Binji, Abdurrahman El-Fulaty Ahmad , Muhd Bashir Kabir, Kabir Umar Bindawa, Armaya’u Ahmed Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria SAGE Open Med . 2021 Feb 1;9:2050312121991246. doi: 10.1177\/2050312121991246. eCollection 2021.<\/p>\n

      2. Gustavo A Arga\u00f1araz, Julys da Fonseca Palmeira, Enrique R Arga\u00f1araz, Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19 Cell Commun Signal . 2020 Dec 27;18(1):190. doi: 10.1186\/s12964-020-00687-7.<\/p>\n

      3. Rachel Audo, Charlotte Hua, Michael Hahne, Bernard Combe, Jacques Morel, Claire I. Daien. Phosphatidylserine outer layer translocation is Implicated in IL-10 secretion by Human Regulatory B Cells PLOS ONE 12(1): e0169755 https:\/\/doi. org\/10.1371\/journal.pone.0169755.<\/p>\n

      4. C A Stokes, R Kaur, M R Edwards, M Mondhe, D Robinson, E C Prestwich, R D Hume, C A Marshall, Y Perrie, V B O’Donnell, J L Harwood, I Sabroe,
      \nL C Parker Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes 2016 Sep;9(5):1303-16. doi: 10.1038\/mi.2015.137. Epub 2016 Feb 24.<\/p>\n

      5. Jennifer Oyler-Yaniv, Alon Oyler-Yaniv, Mojdeh Shakiba, Nina K Min, Ying-Han Chen, Sheue-Yann Cheng, Oleg Krichevsky, Nihal Altan-Bonnet, Gr\u00e9goire Altan- Bonnet Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation Mol Cell. 2017 Jun 1;66(5):635-647.e7. doi: 10.1016\/j.molcel.2017.05.011.<\/p>\n

      6. Hso-Chi Chaung , Chin-Dong Chang, Pi-Hang Chen, Chia-Jung Chang, Shyh- Hwa Liu, Chih-Cheng Chen Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain. Food Chem 2013 May 1;138(1):342-7. doi: 10.1016\/j. foodchem.2012.10.082. Epub 2012 Nov 10.<\/p>\n

      7. Sheldon S Hendler , David M. Rorvik Physicians Desk Reference PDR Integratori Nutrizionali -Nuova Edizione CeC Editore 2010 ; 285-287.<\/p>\n

      8. Lucia A Seale 1 , Daniel J Torres 1 , Marla J Berry 1 , Matthew W Pitts 1 A role for selenium-dependent GPX1 in SARS-CoV-2 virulence. Am J Clin Nutr . 2020 Aug 1;112(2):447-448. doi: 10.1093\/ajcn\/nqaa177.<\/p>\n

      9. C-K Tseng 1 , C-T Ho, H-S Hsu, C-H Lin, C-I Li, T-C Li, C-S Liu, C-C Lin, W Y Lin Selenium is inversely associated with interleukin-6 in the elderly J Nutr Health Aging. 2013 Mar;17(3):280-4. doi: 10.1007\/s12603-012-0376-6. Food Chem 2013 May 1;138(1):342-7. doi: 10.1016\/j.foodchem.2012.10.082. Epub 2012 Nov 10.<\/p>\n

      10. SINU Societ\u00e0 Italiana di Nutrizione Umana LARN-Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana.IV Revisione SICS 2016; 554-564.<\/p>\n

      11. Jinsong Zhang,a,1 Ramy Saad,b,c,1 Ethan Will Taylor,d and Margaret P. Raymanb, Selenium and selenoproteins in viral infection with potential relevance to covid-19. Redox Biol. 2020 Oct; 37: 101715.<\/p>\n

      12. Vyacheslav S Slyshenkov , Dorota Dymkowska, Lech Wojtczak Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics . FEBS Lett . 2004 Jul 2;569(1-3):169-72. doi: 10.1016\/j.febslet.2004.05.044.<\/p>\n

      13. SINU Societ\u00e0 Italiana di Nutrizione Umana LARN-Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana.IV Revisione SICS 2016; 272-284.<\/p>\n

      14. Hillary Kimberly Osorio Landa , Iv\u00e1n P\u00e9rez D\u00edaz 2, Sara Del Carmen Laguna B\u00e1rcenas, Juan Manuel L\u00f3pez Navarro , Mar\u00eda Fernanda Abella Roa , Mariel Corral Orozco, Juan Pablo Mancilla Ortega Diana Alheli Mart\u00ednez Duarte , Susana Isabel Morales Montalvo Sebasti\u00e1n M\u00fazquiz Aguirre Elizabet S\u00e1nchez Landa Association of serum vitamin D levels with chronic disease and mortality. Nutr Hosp. 2020 Apr 16;37(2):335-342. doi: 10.20960\/nh.02512.<\/p>\n

      15. SINU Societ\u00e0 Italiana di Nutrizione Umana LARN-Livelli di Assunzione di Riferimento di Nutrienti ed energia per la popolazione italiana.IV Revisione SICS 2016; 335-354.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      physical and mental fatigue<\/p>\n

      immune system support<\/p>\n","protected":false},"featured_media":2337,"template":"","tags":[413,422,416,423],"product_category":[14,10],"forma_farmaceutica":[281],"produttore":[],"regime_fornitura":[],"gusto_prodotto":[],"caratteristiche":[286,287,285,279,280,278],"ingredienti":[506,489,507,508],"linea":[409],"emozioni":[],"class_list":["post-2335","products","type-products","status-publish","has-post-thumbnail","hentry","tag-antioxidant","tag-immune-defenses","tag-mental-fatigue","tag-physical-fatigue","product_category-food-supplements","product_category-products","forma_farmaceutica-capsules","caratteristiche-allergen-free-patented","caratteristiche-free-from-artificial-sweeteners","caratteristiche-gluten-free","caratteristiche-naturally-lactose-free","caratteristiche-no-added-sugar","caratteristiche-vegan","ingredienti-phosphatidylserine","ingredienti-selenium","ingredienti-vitamin-b5","ingredienti-vitamin-d3","linea-vitamins"],"acf":[],"_links":{"self":[{"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/products\/2335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/products"}],"about":[{"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/types\/products"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/media\/2337"}],"wp:attachment":[{"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/media?parent=2335"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/tags?post=2335"},{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/product_category?post=2335"},{"taxonomy":"forma_farmaceutica","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/forma_farmaceutica?post=2335"},{"taxonomy":"produttore","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/produttore?post=2335"},{"taxonomy":"regime_fornitura","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/regime_fornitura?post=2335"},{"taxonomy":"gusto_prodotto","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/gusto_prodotto?post=2335"},{"taxonomy":"caratteristiche","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/caratteristiche?post=2335"},{"taxonomy":"ingredienti","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/ingredienti?post=2335"},{"taxonomy":"linea","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/linea?post=2335"},{"taxonomy":"emozioni","embeddable":true,"href":"https:\/\/guna.com\/wp-json\/wp\/v2\/emozioni?post=2335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}