{"id":1404,"date":"2022-04-05T14:57:12","date_gmt":"2022-04-05T12:57:12","guid":{"rendered":"https:\/\/guna.com\/?page_id=1404"},"modified":"2024-10-22T11:38:43","modified_gmt":"2024-10-22T09:38:43","slug":"scientific-research","status":"publish","type":"page","link":"https:\/\/guna.com\/about-us\/scientific-research\/","title":{"rendered":"Scientific Research"},"content":{"rendered":"\n
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Every year we work on\u00a0clinical research<\/strong>\u00a0in order to verify and prove the efficacy and safety of our products. Below is a list of studies on molecules and compounds we have researched, used, and published in various prestigious international indexed journals.<\/p>\n\n\n\n 2024<\/p>\n<\/td> Agosti M. et al<\/p>.<\/td> European Review for Medical and Pharmacological Sciences<\/p>\n<\/td> Delphi Consensus<\/p>\n<\/td> A low-dose multicomponent medication as a new approach in prevention and early add-on treatment of recurrent respiratory infections in children: a Delphi Consensus.<\/span><\/p><\/td> Citomix<\/p>\n<\/td><\/tr> 2024<\/p>\n<\/td> Cazzaniga A. et al.<\/p>\n<\/td> J. Biol. Regul. Homeost. Agents<\/span><\/p>\n<\/td> Studio pre-clinico<\/p>\n<\/td> The Different Effects of Pharmacological or Low-Doses of IFN-<\/span>\u03b3<\/em> on Endothelial Cells are Mediated by Distinct Intracellular Signalling Pathways<\/span>.<\/span><\/p><\/td> IFN-<\/span>\u03b3<\/em><\/p>\n<\/td><\/tr> 2023<\/p>\n<\/td> Fioranelli M. et al.<\/p>\n<\/td> Minerva Cardiology and Angiology<\/p>\n<\/td> Clinical study<\/p>\n<\/td> Impact of low-dose Brain-Derived Neurotrophic Factor (BDNF) on atrial fibrillation recurrence.<\/span><\/p><\/td> BDNF<\/p>\n<\/td><\/tr> 2023<\/p>\n<\/td> Iuliano M. et al.<\/p>\n<\/td> Current Medicinal Chemistry<\/p>\n<\/td> In vitro<\/em> study<\/p>\n<\/td> Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model.<\/p>\n<\/td> IL-10 2020<\/p>\n<\/td> Migliore A. AboutOpen<\/p>\n<\/td> Pharmaco-economic study<\/p>\n<\/td> Economic evaluation of low-dose SKA cytokines in patients with rheumatoid arthritis in maintaining low disease activity or remission.<\/p>\n<\/td> IL-4 2020<\/p>\n<\/td> Genazzani A. D. et al.<\/p>\n<\/td> Endocrines<\/p>\n<\/td> Observational study<\/p>\n<\/td> Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study.<\/p>\n<\/td> \u03b2-ESTRADIOL<\/p>\n<\/td><\/tr> 2020<\/p>\n<\/td> Molinari C. et al.<\/p>\n<\/td> Brain Sciences<\/p>\n<\/td> In vitro <\/em>and in animal model basic research<\/p>\n<\/td> The Role of BDNF on Aging-Modulation Markers. <\/p>\n<\/td> BDNF<\/p>\n<\/td><\/tr> 2019<\/p>\n<\/td> Benvenuto M. et al.<\/p>\n<\/td> Experimental and Therapeutic Medicine<\/p>\n<\/td> In vitro<\/em> basic research<\/p>\n<\/td> Effects of a natural multi\u2010component compound formulation on the growth, morphology and extracellular matrix production of human adult dermal fibroblasts.<\/p>\n<\/td> GALIUM-HEEL<\/p>\n<\/td><\/tr> 2018<\/p>\n<\/td> Tagliacarne S. C. et al.<\/p>\n<\/td> Immunology Letters<\/p>\n<\/td> In vivo <\/em>basic research<\/p>\n<\/td> Low Dose<\/em> multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery.<\/p>\n<\/td> CITOMIX<\/p>\n<\/td><\/tr> 2018<\/p>\n<\/td> Uberti F. et al.<\/p>\n<\/td> Wound<\/p>\n<\/td> In vivo <\/em>basic research<\/p>\n<\/td> Highly Diluited Acetylcholine Promotes Wound Repair in an In Vivo<\/em> Model<\/p>\n<\/td> ACH<\/p>\n<\/td><\/tr> 2018<\/p>\n<\/td> Mancini F. et al.<\/p>\n<\/td> International Immunopharmacology<\/p>\n<\/td> In vitro<\/em> basic research<\/p>\n<\/td> Low Dose<\/em> SKA progesterone and Interleukin-10 modulate inflammatory pathway cytokines in endometriotic cell lines.<\/em><\/p>\n<\/td> IL-10<\/p>\n PROGESTERON<\/p>\n<\/td><\/tr> 2017<\/p>\n<\/td> Castiglioni S. et al.<\/p>\n<\/td> International Journal of Molecular Sciences<\/p>\n<\/td> In vitro<\/em> basic research<\/p>\n<\/td> Femtograms of Interferon-gamma Suffice to Modulate the Behavior of Jurkat Cells: A New Light in Immunomodulation.<\/p>\n<\/td> IFN-\u03b3<\/p>\n<\/td><\/tr> 2017<\/p>\n<\/td> Carello R. et al.<\/p>\n<\/td> Italian Journal of Pediatrics<\/p>\n<\/td> Clinical Trial<\/p>\n<\/td> Long-term treatment with Low Dose<\/em> Medicine<\/em> in chronic childhood eczema. A double-blind two-stage randomized control trial.<\/p>\n<\/td> IL-12<\/p>\n IFN-\u03b3<\/p>\n<\/td><\/tr> 2017<\/p>\n<\/td> Martin Martin L. S. et al.<\/p>\n<\/td> Drug Design, Development and Therapy<\/p>\n<\/td> Clinical Trial<\/p>\n<\/td> An open randomized active-controlled clinical trial with Low Dose<\/em> SKA cytokines versus DMARDs evaluating low disease activity maintenance in patients with rheumatoid arthritis.<\/p>\n<\/td> ANTI IL-1<\/p>\n IL-4<\/p>\n IL-10<\/p>\n<\/td><\/tr> 2017<\/p>\n<\/td> Tessaro I. et al.<\/p>\n<\/td> J Reprod Infertil.<\/p>\n<\/td> In vivo<\/em> basic research<\/p>\n<\/td> Ultra Low Dose<\/em> of Follicle Stimulating Hormone and Progesterone attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized Mouse Model.<\/p>\n<\/td> FSH<\/p>\n PROGESTERON<\/p>\n<\/td><\/tr> 2016<\/p>\n<\/td> Uberti F. et al<\/p>\n<\/td> Cells Tissues Organs<\/p>\n<\/td> In vitro<\/em> basic research<\/p>\n<\/td> Stimulation of the Non-neuronal Cholinergic System by Highly Diluted Acetylcholine in Keratinocytes.<\/p>\n<\/td> ACH<\/p>\n<\/td><\/tr> 2016<\/p>\n<\/td> Genazzani A. et al<\/p>\n<\/td> Frontiers in Gynecological Endocrinology<\/p>\n<\/td> Observational study<\/p>\n<\/td> Pharmacological and Integrative Treatment of Stress-Induced Hypothalamic Amenorrhea.<\/p>\n<\/td> \u03b2-ESTRADIOL<\/p>\n<\/td><\/tr> 2016<\/p>\n<\/td> Fiorito F. et al.<\/p>\n<\/td> Comparative Immunology, Microbiology and Infectious Diseases<\/p>\n<\/td> Veterinary study<\/p>\n<\/td> Clinical improvement of cows with puerperal metritis treated with the homeopathic product 0.01% abies alba and the low dose of neostigmine.<\/p>\n<\/td> NEOSTIGMIN<\/p>\n<\/td><\/tr> 2016<\/p>\n<\/td> Barygina V. et al.<\/p>\n<\/td> Journal of Dermatological Science<\/p>\n<\/td> In vivo<\/em> basic research<\/p>\n<\/td> Low Dose<\/em> cytokines reduce oxidative stress in primary lesional fibroblasts obtained from psoriatic patients.<\/p>\n<\/td> IL-4<\/p>\n IL-10<\/p>\n FGF-\u03b2<\/p>\n \u03b2-ENDORPHIN<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Tessaro et al.<\/p>\n<\/td> Journal of Ovarian Research<\/p>\n<\/td> In vivo<\/em> basic research<\/p>\n<\/td> Effect of oral administration of Low Dose<\/em> follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome<\/p>\n<\/td> FSH<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Lotti T. et al<\/p>\n<\/td> Der Hautarzt<\/p>\n<\/td> Observational retrospective study<\/p>\n<\/td> Successful combination treatment for Psoriasis with phototherapy and Low Dose<\/em> Cytokines.<\/p>\n<\/td> IL-4<\/p>\n IL-10<\/p>\n ANTI IL-1<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Radice E. et al<\/p>\n<\/td> Translational oncology<\/p>\n<\/td> Ex vivo<\/em> basic research<\/p>\n<\/td> Enhancement of the immunomodulatory functions of ex vivo-generated dendritic cells from early-stage colon cancer patients by consecutive exposure to Low Doses<\/em> of sequential kinetic activated IL-4 and IL-12. A preliminary study.<\/p>\n<\/td> IL-4<\/p>\n IL-12<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Lotti T. et al<\/p>\n<\/td> Journal of Biological Regulatory & Homeostatic Agents<\/p>\n<\/td> Clinical Trial<\/p>\n<\/td> Vitiligo: successful combination treatment based on oral Low Dose<\/em> cytokines and di\u00adfferent topical treatments.<\/p>\n<\/td> IL-4<\/p>\n IL-10<\/p>\n ANTI IL-1<\/p>\n FGF-\u03b2<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Barygina V. et al<\/p>\n<\/td> Journal of Dermatological Science<\/p>\n<\/td> In vitro<\/em> basic research<\/p>\n<\/td> Treatment with Low Dose<\/em> cytokines reduces oxidative-mediated injury in perilesional keratinocytes from vitiligo skin.<\/p>\n<\/td> IL-4<\/p>\n IL-10<\/p>\n FGF-\u03b2<\/p>\n \u03b2-endorphin<\/p>\n<\/td><\/tr> 2015<\/p>\n<\/td> Luchetti P.<\/p>\n<\/td> Minerva Medica Oftalmologica<\/p>\n<\/td> Observational retrospective study<\/p>\n<\/td> Increasing of visual function in patients with retinal atrophy treated with drugs of Low Dose<\/em> Medicine<\/em>.<\/p>\n<\/td> NT 3<\/p>\n NT4<\/p>\n NGF<\/p>\n<\/td><\/tr> 2014<\/p>\n<\/td> Radice E. et al.<\/p>\n<\/td> International Immunopharmacology<\/p>\n<\/td> Ex vivo<\/em> basic research<\/p>\n<\/td> Low Doses<\/em> of sequential-kinetic-activated interferon-gamma enhance the ex vivo cytotoxicity of peripheral blood natural killer cells from patients with early-stage colorectal cancer. A preliminary study<\/em><\/p>\n<\/td> IFN-\u03b3<\/p>\n<\/td><\/tr> 2014<\/p>\n<\/td> Roberti M. L. et al.<\/p>\n<\/td> Journal of Biological Regulatory & Homeostatic Agents<\/p>\n<\/td> Clinical Trial<\/p>\n<\/td> Immunomodulating treatment with Low Dose<\/em> interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris<\/p>\n<\/td> IL-4<\/p>\n IL-10<\/p>\n<\/td><\/tr> 2013<\/p>\n<\/td> Cardani D. et al.<\/p>\n<\/td> Gastroenterology Research<\/p>\n<\/td> In vivo<\/em> basic research<\/p>\n<\/td> Oral administration of Interleukin-10 and Anti-IL-1 Antibody ameliorates experimental intestinal inflammation.<\/p>\n<\/td> IL-10<\/p>\n ANTI IL-1<\/p>\n<\/td><\/tr> 2012<\/p>\n<\/td> D\u2019amico L. et al.<\/p>\n<\/td> Journal of Cancer Therapy<\/p>\n<\/td> Ex vivo<\/em> basic research<\/p>\n<\/td> Low Dose<\/em> of IL-12 stimulates T Cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer Patients.<\/em><\/p>\n<\/td> IL-12<\/p>\n<\/td><\/tr> 2009<\/p>\n<\/td> Gariboldi S. et al.<\/p>\n<\/td> Pulmonary Pharmacology & Therapeutics<\/p>\n<\/td> In vivo<\/em> basic research<\/p>\n<\/td> Low Dose<\/em> oral administration of cytokines for treatment of allergic asthma.<\/p>\n<\/td> IL-12<\/p>\n IFN-\u03b3<\/p>\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n 2023<\/p><\/td> Romasco T. et al.<\/p><\/td> Biomedicines<\/p><\/td> In vitro<\/em> study<\/p><\/td> Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study<\/p><\/td> DENTAL SKIN BIOREGULATION<\/p><\/td><\/tr> 2020<\/p><\/td> Randelli F. et al.<\/p><\/td> Cells<\/p><\/td> Ex vivo<\/em> basic research<\/p><\/td> The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes.<\/p><\/td> MD-TISSUE<\/p><\/td><\/tr> 2020<\/p><\/td> Corrado B. et al.<\/p><\/td> Journal of Human Sport & Exercise<\/p><\/td> Observational study<\/p><\/td> Ultrasound-guided collagen injections for treatment of plantar fasciopathy in runners: A pilot study and case series<\/em>.<\/p><\/td> GUNA COLLAGEN MDs<\/p><\/td><\/tr> 2020<\/p><\/td> Corrado B. et al.<\/p><\/td> Oxford Medical Case Reports<\/p><\/td> Case report<\/em><\/p><\/td> Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report<\/em>.<\/p><\/td> GUNA COLLAGEN MDs<\/p><\/td><\/tr> 2020<\/p><\/td> Migliore A. AboutOpen<\/p><\/td> Pharmaco-economic study<\/p><\/td> Analisi di minimizzazione dei costi di MD-Knee rispetto all\u2019acido ialuronico nel trattamento di pazienti con osteoartrosi del ginocchio.<\/p><\/td> MD-KNEE<\/p><\/td><\/tr> 2020<\/p><\/td> Micarelli A. et al.<\/p><\/td> Eurpean Journal of Physical and Rehabilitation Medicine<\/p><\/td> Clinical Study<\/p><\/td> Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial.<\/p><\/td> GUNA COLLAGEN MDs<\/p><\/td><\/tr> 2019<\/p><\/td> Corrado B. et al.<\/p><\/td> Muscles, Ligaments and Tendons Journal<\/p><\/td> Observational study<\/p><\/td> Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study.<\/p><\/td> GUNA COLLAGEN MDs<\/p><\/td><\/tr> 2019<\/p><\/td> Pavelka K. et al.<\/p><\/td> Physiol. Res.<\/p><\/td> Clinical Study<\/p><\/td> Efficacy and Tolerability of Injectable Collagen-Containing Products in Comparison to Trimecaine in Patients With Acute Lumbar Spine Pain (Study FUTURE-MD-Back Pain).<\/p><\/td> MD-LUMBAR 2019<\/p><\/td> Godek P.<\/p><\/td> Ortopedia Traumatologia Rehabilitacja<\/p><\/td> Clinical Study<\/p><\/td> Collagen Therapy in Lumbar Spondylosis \u2013 a Pilot Study. Does the Route of Administration Matter?<\/p><\/td> MD-NEURAL 2018<\/p><\/td> Nitecka-Buchta A. et al.<\/p><\/td> Pain Research and Management<\/p><\/td> Clinical Study<\/p><\/td> Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial.<\/p><\/td> MD-MUSCLE<\/p><\/td><\/tr> 2018<\/p><\/td> Randelli F. et al.<\/p><\/td> Cells<\/p><\/td> Ex vivo<\/em> basic research<\/p><\/td> Effect of a Collagen-Based Compound on Morpho-Functional Properties of Cultured Human Tenocytes.<\/p><\/td> MD-TISSUE<\/p><\/td><\/tr> 2016<\/p><\/td> Martin-Martin L. S. et al.<\/p><\/td> BMC Musculoskeletal Disorders<\/p><\/td> Clinical Trial<\/p><\/td> A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis (\u201cJoint\u201d).<\/p><\/td> MD-KNEE<\/p><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n 2021<\/p><\/td> Tassinari R.<\/p><\/td> BMC Complementary Medicine and Therapies<\/p><\/td> In vitro<\/em> basic research<\/p><\/td> Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells.<\/p><\/td> EPATOGUNA<\/p><\/td><\/tr> 2021<\/p><\/td> Berni P.<\/p><\/td> Applied Sciences<\/p><\/td> In vitro<\/em> basic research<\/p><\/td> In Vitro Evaluation of Cytotoxicity and Proliferative Effects of Lyophilized Porcine Liver Tissue on HepG2 Hepatoma Cells and Adipose-Tissue-Derived Mesenchymal Stromal Cells.<\/p><\/td> EPATOGUNA<\/p><\/td><\/tr> 2019<\/p><\/td> Duranti S. et al.<\/p><\/td> Plos One<\/p><\/td> In vitro<\/em> basic research<\/p><\/td> Exploring the effects of Colostrononi on the mammalian gut microbiota composition.<\/p><\/td> COLOSTRONONI<\/p><\/td><\/tr> 2016<\/p><\/td> Chisari G. et al.<\/p><\/td> Minerva Oftalmol<\/p><\/td> Observational study<\/p><\/td> La cosomministrazione dei ceppi batterici Lactobacillus<\/em> e Bifidobacterium<\/em> in associazione con frutto-oligosaccaridi a corta catena riduce il danno alla superficie oculare causato dalla sindrome dell\u2019occhio secco.<\/p><\/td> PROFLORA<\/p><\/td><\/tr> 2014<\/p><\/td> Lozzi A.<\/p><\/td> Minerva Cardioangiol<\/p><\/td> Observational retrospective study<\/p><\/td> Overview sulle strategie di trattamento farmacologico e nutraceutico della dislipidemia border-line<\/p><\/td> OMEGA-FORMULA<\/p><\/td><\/tr> 2014<\/p><\/td> Cardani D.<\/p><\/td> Inflammation Cell Signaling<\/p><\/td> Review<\/p><\/td> New perspective in dietary supplementation: bovine colostrum and noni juice synergic protective effects on intestinal epithelium and microbiota<\/p><\/td> COLOSTRONONI<\/p><\/td><\/tr> 2014<\/p><\/td> Cardani D.<\/p><\/td> Minerva Gastroenterol Dietol<\/p><\/td> Ricerca di base in vitro<\/em><\/p><\/td> Effetti di Colostrononi sul turnover delle cellule epiteliali, sugli stati infiammatori e sull\u2019integrit\u00e0 dei sistemi giunzionali della mucosa intestinale.<\/p><\/td> COLOSTRONONI<\/p><\/td><\/tr> 2012<\/p><\/td> Roncuzzi A. et al.<\/p><\/td> Giornale Italiano di Ostetricia e Ginecologia<\/p><\/td> Clinical Trial<\/p><\/td> Efficacia e tollerabilit\u00e0 di Ferroguna
Scientific research is an integral part of our identity as a business because it is much more than just the instrument through which we can construct. It is a key element for helping to build a better future for everyone.<\/p>\n\n\n\nResearch in Low Dose Medicine<\/h2><\/div>\n\n\n\n
YEAR<\/th> AUTHORS<\/th> JOURNAL<\/th> RESEARCH TYPE<\/th> TITLE<\/th> MOLECULES OR COMPOUNDS<\/th><\/tr><\/thead> \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
Anti-IL 1<\/p>\n<\/td><\/tr>\n \n
Ravasio R.<\/p>\n<\/td>\n \n \n \n
IL-10
Anti-IL 1<\/p>\n<\/td><\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n Medical Devices research<\/h2><\/div>\n\n\n\n
Year<\/th> Authors<\/th> Journal<\/th> Research type<\/th> Title<\/th> Medical Device<\/th><\/tr><\/thead>
Ravasio R.<\/p><\/td>
MD-NEURAL
MD-MUSCLE<\/p><\/td><\/tr>
MD-LUMBAR<\/p><\/td><\/tr>Food Supplements research<\/h2><\/div>\n\n\n\n
Year<\/th> Authors<\/th> Journal<\/th> Research type<\/th> Title<\/th> Food Supplement<\/th><\/tr><\/thead>