GUNA cooperates with Italian and international Universities and Research Institutes for many purposes, as illustrated below.
(Interdepartmental Research Centre for the study of the biological effects of Nano-concentrations)
Framework agreement between GUNA and the University of Milan, Italy
Over the last few years, a new trend of research has begun to spread throughout the world aimed at investigating the biological effects of low-dose concentrations of active ingredients and natural biological substances. The possible fields of application are very appealing because many results show they are effective and without side effects.
In several countries of the world and especially in Italy, Research studies on the effects of nano-concentrations have been focusing on messenger molecules (cytokines and interferon, hormones and neuropeptides, growth factors) and the possibility of using them for therapeutic purposes. The first studies and the publications of their results have aroused the interest of the scientific community on this new direction and their prospective clinical application. To better understand the specific mechanisms of action of nano-concentrations, in January 2012 the Interdepartmental Research Center for the Study of Biological Effects of Nano-concentrations (CREBION) was founded at the University of Milan, Italy. In May 2012 GUNA, the Italian leader for low dose medicine, has undersigned a framework agreement on scientific cooperation.
Many scientific and technical cooperation activities have already been started. For additional information, please visit the web site www.crebion.unimi.it
AIMS AND PURPOSES:
The aim of the Interdepartmental Research Center for the Study of Biological Effects of Nano-concentrations (CREBION) is the study of the mechanisms of action and the effects of low concentrations of substances and active ingredients for treating human and animal diseases to ensure their well-being.
This Center is intended to be a reference point of excellence for anyone who want to evaluate the effectiveness of low dose formulations by using experimental models and rigorous, innovative and multidisciplinary methods.
For this purpose, CREBION intends to create a cross network across different scientific fields, with the aim of finalizing joint research projects.
Scientific expertise and numerous ongoing cooperations among different organizations, allowed CREBION to be a reference organization in terms of excellence and amount of research studies for Public Institutions, Companies and individual Research Groups, both nationally and internationally.
OTHER SCIENTIFIC AND RESEARCH COOPERATIONS
Institute of Human Morphology, University of Milan, Italy
Scientific cooperation in the study of basic research “Low dose oral administration of cytokines for treatment of Crohn’s disease” – September 2009.
Scientific cooperation in the study of basic research “Low dose oral administration of cytokines for treatment of allergic asthma” – May 2009.
References: S. Gariboldi, M. Palazzo, L. Zanobbio, G. F. Dusio, V. Mauro, U. Solimene, D. Gimbals, M. Mantovani and C. Rumio, “Low Dose Oral Administration of Cytokines for Treatment of Allergic Asthma”, Pulmonary Pharmacology & Therapeutics, Vol 22, No. 6, 2009, p. 497-510.
Scientific cooperation in the study of basic research “Activity of low dose growth factors on human fibroblasts”.
DEPARTMENT OF ANIMAL SCIENCE, UNIVERSITY OF MILAN, ITALY
Scientific cooperation in the study of basic research “Study of the effect of low dose hormones preparation administration on DHEA treated mice as model for polycistic ovary syndrome (PCOs)”.
References: Modina Silvia Clotilde, Irene Tessaro, Lodde Valentina, Patrizia Luchini, Franciosi Federica, Corbani David Rumio Christian, Alberto Maria Luciano, “Effect of low doses of FSH and P4 on cystogenesis-induced mice as in polycystic ovary syndrome model”, Poster Presentations / European Journal of Integrative Medicine 4S (2012) 124-201.
CERMS (RESEARCH CENTRE FOR EXPERIMENTAL MEDICINE), UNIVERSITY HOSPITAL SAN GIOVANNI BATTISTA – MOLINETTE HOSPITAL – TURIN, ITALY
Scientific cooperation in the study of basic research “Effects of low dose cytokines (IL -12) on PBMC of human lung carcinoma in vitro” – December 2011.
References: L. D’Amico , E. Ruffini , R. Ferracini , Roato I. “Low Dose IL-12 stimulates T cell response in cultures of PBMCs derived from Non Small Cell Lung Cancer patients”, Journal of Cancer Therapy, 2012, 3, pp.337-342.
DEPARTMENT OF MEDICINE AND SURGERY. SURGICAL ONCOLOGY, UNIVERSITY OF TURIN, ITALY
Scientific cooperation in the study of basic research ex vivo “The action of low-dose IFN- γ on the functional activity of NK cells in patients with colorectal carcinoma” – November 2008.
Reference: Radice E. , “The action of low-dose IFN- γ on the functional activity of NK cells in patients with colorectal carcinoma : a preliminary study” , 1st Congress Pre-clinical and clinical approaches to the use of low doses. University of Milan, September 29 2012.
RESEARCH CENTRE “CUOREINSALUTE”, DEPARTMENT OF PREVENTIVE CARDIOLOGY REHABILITATION GENERAL HOSPITAL OF MONZA, ITALY
DIVISION OF CARDIOLOGY, UNIVERSITY OF PARMA, ITALY
EXERCISE AND SPORT SCIENCE FACULTY, UNIVERSITY CATTOLICA SACRO CUORE, MILAN, ITALY
Scientific cooperation in the clinical study “Arnica comp.-Heel in Cardiovascular Medicine Rehabilitation: evaluation of the anti-inflammatory, analgesic, functional and clinical effects on individual course of treatment” – November 2008.
Reference: 69th National Congress of the Italian Society of Cardiology.
DEPARTMENT OF EARTH SCIENCES, UNIVERSITY OF PAVIA, ITALY
Scientific cooperation in the study of basic research: “The effectiveness of the homeopathic remedy Zeel T verified by new models of in vitro trials” – July 1996.
Reference: La Medicina Biologica 3/96.
CHAIR OF PLASTIC SURGERY – UNIVERSITY ” LA SAPIENZA”, ROME, ITALY
Scientific cooperation in for the clinical trial: “Regressive vicariation of hypertrophic scars by homotoxicological treatment” – January 1999.
Reference: La Medicina Biologica 1/99.
LABORATORY OF ANIMAL IMMUNOPROPHYLAXIS AND WELFARE – INSTITUTE FOR ANIMAL PROPHYLAXIS OF LOMBARDIA AND EMILIA ROMAGNA, ITALY
Scientific cooperation in the study of basic research: “Anti-inflammatory activity of low- dose IFN- α . In vitro study of pig leukocytes” – January 2007.
Reference: La Medicina Biologica 1/07.
Scientific cooperation in the clinical trial: “Oral administration of alpha interferon to piglets for the control of PRRS and PMWS / PDNS” – April 2002.
Reference: L’Osservatorio 2002/4.
PEDIATRIC GASTROENTEROLOGY CLINIC OF KIEV GORODSKOI DETSKII GASTROENTEROLOGICHESKII CENTR – KIEV, UKRAINE
Scientific publication: “Prophylaxis and treatment of diseases of the oral cavity in children with intestinal disorders”, Biological Therapy, n.1, 2006.
UKRAINIAN MILITARY MEDICAL ACADEMY OF THE DEFENSE MINISTRY OF UKRAINE INSTITUTE OF PEDIATRICS, OBSTETRICS AND GYNECOLOGY – AMS, UKRAINE
Scientific publication: “The effectiveness of Micox, Traumeel S (Arnica comp.-Heel) and Lymphomysot in combination therapy of urogenital candidiasis”, Woman’s reproductive health 4 (29), 2006, pp.128-130.
CRIMEAN MEDICAL UNIVERSITY NAMED AFTER S.I. GEORGIEVSKIY, SIMFEROPOL, UKRAINE
Scientific publication: “Use of homotoxic preparations in combination treatment of degenerative spinal dystrophic diseases”, Biological Therapy, n.1, 2006, pp.43-45.
UNIVERSITY OF THE PHILIPPINES – PHILIPPINE GENERAL HOSPITAL IN MANILA, PHILIPPINES
Scientific publication: “Safety and efficacy of mesotherapy in the treatment of localized fat deposits in Filipino adult females: a randomized double-blind clinical trial”, Physiological Regulating Medicine 2008.
DEPARTMENT – FACULTY OF MEDICINE AND PHARMACOLOGY “N. TESTEMITANU”, CHISINAU, REPUBLIC OF MOLDOVA
Scientific publication: “The combined treatment of chronic viral hepatitis B, C, and mixed B and C with Citomix + GUNA Liver + Interferon gamma 4CH”, Curierul Medical n.5 (317), 2010.
INSTITUTE OF GERONTOLOGY, AMS, UKRAINE
Scientific publication: “Evaluation of efficacy and safety of Osteobios systemic on prevention of osteoporosis in postmenopausal women”.
M.D. UNIVERSITY ASSISTANT DEPARTMENT OF INTERNAL MEDICINE, STATE UNIVERSITY OF MEDICINE AND PHARMACY “NICOLAE TESTEMITANU” REPUBLIC OF MOLDOVA
Scientific publication: “Study Project: clinical assessment of patients with Rheumatoid arthritis treated with metotrexat as monotherapy and combined therapy methotrexat and GUNA-Flam”.
DEPARTMENT OF CONTAGIOUS DISEASES, NICOLAE TESTEMITANU STATE MEDICAL AND PHARMACEUTICAL UNIVERSITY 163, STEFAN CEL MARE AVENUE, CHISINAU, REPUBLIC OF MOLDOVA
Scientific publication: “The Treatment of Patients with Chronic Viral Hepatitis C with Citomix”.
CLINICAL STUDIES (CLINICAL RESEARCH PROJECT CRP)
OPERATING UNIT OF IMMUNOLOGY AND ALLERGOLOGY OF DEVELOPMENTAL AGE- SAN PIETRO FATEBENEFRATELLI HOSPITAL, ROME, ITALY
Scientific cooperation in the clinical study: Atopic dermatitis “Clinical and Immunological Evaluation of a long-term treatment with Physiological Regulating Medicine in Children suffering from chronic atopic Dermatitis. Experimental, randomized, double-blind, two-stage trial”.
DEPARTMENT OF MEDICAL AND SURGICAL SCIENCES – UNIVERSITY OF BOLOGNA, ITALY
Scientific cooperation in the clinical trial: FerroGUNA “Multicenter, randomized, controlled, parallel group trial to evaluate the efficacy and tolerability of FerroGUNA compared to Ferro-Grad in the treatment of iron deficiency anemia in pregnant subjects beyond the 12th week of amenorrhea” – Study completed and published in Giornale Italiano di Ostetricia e Ginecologia (Italian Journal of Obstetrics and Gynecology), November-December 2012.
SAN PATRIGNANO HOSPITAL – RIMINI, ITALY
Scientific cooperation in the clinical study: “HCV Study “Pilot case-control study with low dose cytokines SKA physiological and biological drugs in patients with chronic HCV hepatitis: analysis of safety and efficacy”.
SERT VILLAFRANCA DI VERONA – VERONA, ITALY
Scientific cooperation in the clinical trial: HCV Study “Case-control pilot study with low dose SKA cytokines and non-conventional medicines in patients with chronic HCV hepatitis: analysis of safety and efficacy”.
PEDIATRIC CLINIC – POLICLINICO (GENERAL HOSPITAL) GB ROSSI – VERONA, ITALY
Scientific cooperation in the clinical trial: “Low Height Evaluation of the effectiveness of a treatment of idiopathic short height and/or growth arrest with Physiological Regulating Medicine”.
PEDIATRIC ALLERGOLOGY SURGERY – OSPEDALE NUOVO REGINA MARGHERITA (HOSPITAL) – ROME, ITALY
Scientific cooperation in the clinical trial: Food allergies “Clinical and immunological evaluation of a treatment of IgE-mediated and non- IgE mediated food allergies with Allergy Plex in children: a pilot study”.
MVM MICROSURGERY – VILLA MASSIMO – ROMA, ITALY
Scientific cooperation in the clinical trial: Retinal Atrophy “Case-control pilot trial on visual function in subjects with retinal atrophy using Physiological Regulating Medicine and Antihomotoxic medicines”.
FONDAZIONE LA ROSA D’ARGENTO (FOUNDATION) – RONCO BRIANTINO (MONZA BRIANZA), ITALY
FONDAZIONE LA PELUCCA (FOUNDATION) – SESTO SAN GIOVANNI (MILANO), ITALY
RESIDENZA SACCARDO (NURSING HOME FOR ELDERLY) – MILAN, ITALY
Scientific cooperation in “Multicenter, prospective, cohort clinical trial to evaluate the efficacy of GUNA Interleukin -7 in combination with the flu vaccine to strengthen the immune system in elderly patients hospitalized in a nursing home for the treatment of infectious respiratory episodes in winter: Clinical trial “INFLUBOOSTER”.
OPERATING UNIT OF RHEUMATOLOGY – SAN PIETRO FATEBENEFRATELLI HOSPITAL – ROME, ITALY
Scientific cooperation in: “Multicenter, double-blind, randomized, controlled clinical trial on the intra-articular use of MD-KNEE versus sodium hyaluronate in patients with osteoarthritis of the knee. Clinical trial “JOINT”.
Scientific cooperation in the clinical trial: Rheumatoid Arthritis “Randomized, controlled trial on maintaining low disease activity by administering dynamized low dose cytokines compared to standard therapy (DMARDS) in the management of arthritis (CIDAI study)”.
DEPARTMENT OF CLINICAL PATHOPHYSIOLOGY – UNIVERSITY OF TURIN, ITALY
Scientific cooperation in the clinical trial: “Study of the effect of GUNA-Interferon gamma and GUNA-Interleukin 4 on the ex vivo functional activity of Natural Killer and dendritic cells in patients with cancer of the colon, rectum and anus”.
POST-MARKETING STUDIES ON MEDICAL DEVICES
CENTER OF INTEGRATIVE MEDICINE, SOFIA, BULGARIA
Cooperation in the clinical assessment: “Reduction of adiposity in women with MD-Matrix (abdominal through acupuncture)”.
REVMATOLOGICKÝ ÚSTAV, PRAHA 2, NA SLUPI 4, CZECH REPUBLIC
Cooperation in the clinical trial: “Single-blind, multicentre, comparative clinical trial of Guna MD-Muscle, Neural and Lumbar vs. trimecain in subcutaneous (s.c.) injection in patients with chronic low back pain in the Czech Republic”.
UNIVERSITY OF MILANO-BICOCCA – MILAN, ITALY
Osservatorio e Metodi per la Salute (OsMeSa) (Observatory and Methods for Health –Association for Person-Centered Medicine ONLUS (non-profit social utility organization).
First level master’s degree in “Health Systems, Traditional and Non Conventional Medicine” – Academic Year 2011-2012, 2012-2013.
UNIVERSITY OF MILAN – CENTRE FOR RESEARCH IN MEDICAL BIOCLIMATOLOGY – BIOTECHNOLOGY – NATURAL MEDICINES – MILAN, ITALY
Educational cooperation for the Postgraduate Course of the Faculty of Medicine and Surgery in “Biological Regulation and Complementary Medicine” – Academic Year 2008-2009, 2009-2010, 2010-2011, 2011-2012, 2012-2013.
DEPARTMENT OF DEVELOPMENTAL AGE – CHAIR OF PEDIATRIC CLINIC, UNIVERSITY OF PARMA – PARMA, ITALY
Educational cooperation for the Postgraduate Course of the Faculty of Medicine and Surgery on “Low Dose Medicine in Pediatrics” – Academic Year 2011-2012, 2012-2013.
DEPARTMENT OF MORPHOLOGICAL, EIDOLOGICAL AND CLINICAL SCIENCES, UNIVERSITY OF PAVIA – PAVIA, ITALY
Educational cooperation for the Teaching Course for Coordinators of Integrated Medicine – Academic Year 2012-2013.
DEPARTMENT OF PHARMACEUTICAL SCIENCES, UNIVERSITY OF CALABRIA – ITALY
Educational cooperation for the 1st and 2nd level Master of High University Education “Phytotherapy and Homotoxicology” – Academic Year 2005-2006/2006-2007.
STRITCH SCHOOL OF MEDICINE – LOYOLA UNIVERSITY – CHICAGO, USA
Educational cooperation for the Symposium “Scientific Bases of Physiological Regulating Medicine”, Chicago – November 2007.
UNIVERSITY OF MIAMI, USA
Educational cooperation for the Symposium “Scientific Bases of Physiological Regulating Medicine”, Miami – June 2008.
SCHOOL OF MEDICINE – UNIVERSITY OF WISCONSIN, USA
Communication on “Physiological Regulating Medicine in Pain Management” at the “Fourth Annual Prolotherapy Research Forum” – October 2008.
ASU – ARIZONA STATE UNIVERSITY, USA
Communication on “Physiological Regulating Medicine in Pain Management” – May 2009.
ROYAL SOCIETY OF MEDICINE – LONDON, UK
Communication on “Physiological Regulating Medicine in primary care” – November 2010.
DIVISION OF INTEGRATIVE MEDICINE – MILLER SCHOOL OF MEDICINE – UNIVERSITY OF MIAMI, USA
Communication on “Physiological Regulating Medicine. Scientific bases and basic research” – November 2010.
UNIVERSITY OF TBILISI, GEORGIA
Communication on “Physiological Regulating Medicine – From Basic Research to the evidence of efficacy until the clinical applications” – November 2011.